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Published on: February 26, 2013
Aspirin prescribing pattern and guidelines-adherence evaluation for primary prevention of cardiovascular diseases at
Salman Almalki1, Abdulaziz Alhossan2,3, Bashayer Alrumayyan2
1College of Pharmacy, Riyadh Elm University, Riyadh, Saudi Arabia.
Insights
Many patients inappropriately use aspirin for cardiovascular disease prevention. This study found significant deviations from guidelines, highlighting a need for better education and adherence among healthcare providers to prevent complications.
Area of Science:
- Cardiology
- Pharmacology
- Public Health
Background:
- Cardiovascular diseases (CVDs) remain a leading cause of mortality globally.
- Aspirin is widely used for primary CVD prevention, but its use must align with established guidelines.
- Inappropriate aspirin prescribing can lead to adverse events without proven benefit.
Purpose of the Study:
- To evaluate aspirin prescribing patterns for primary CVD prevention.
- To assess adherence to international guidelines for aspirin use in a teaching hospital setting.
- To identify potential overuse and underuse of aspirin in patient populations.
Main Methods:
- Retrospective analysis of 816 patients receiving aspirin for primary CVD prevention.
- Assessment of patient demographics, comorbidities (diabetes, hypertension, dyslipidemia), and BMI.
- Application of aspirin candidacy calculations based on international recommendations.
Main Results:
- A significant proportion of patients (23%) were on aspirin without clear indication.
- Only 6% of patients met criteria for high recommendation, while 49% had reasonable recommendation.
- The majority of patients were obese (85.78%) and had multiple comorbidities.
Conclusions:
- Current aspirin prescribing for primary CVD prevention in the studied population deviates significantly from international guidelines.
- There is a notable prevalence of inappropriate aspirin use, necessitating improved adherence and education.
- Further research is crucial to understand prescribing patterns and mitigate aspirin-associated risks.
Abstract:
The present study investigates the aspirin prescribing pattern and guidelines-adherence evaluation for primary prevention of cardiovascular diseases at a teaching hospital. A total of 816 patients were included in the study, the patients who received aspirin aged 60-69 (29.65%), followed by patients aged 50-59 years old (29.53%) and 70-79 years old (22.91%). Demographic information shown that the majority of the patients were males (58.55%). The BMI revealed that 85.78% of patients were obese. The majority of the patients have diabetes 78.67%, hypertension 74.38%, and dyslipidemia 65.68%. The mean systolic blood pressure was 136 ± 7.4 and diastolic blood pressure was 74.9 ± 5.2. After applying aspirin candidacy calculation, only 6% patients were highly recommended to be on aspirin, 49% patients had reasonable recommendation of aspirin, 27% patients use aspirin based on "may be considered" recommendation, and 23% patients were on aspirin with no indication or recommendation. The study highlights the importance of following the international recommendations in aspirin prescribing, and flags the inappropriate use and prescribing by our healthcare providers. The current study encourages further investigation to be carried out which should include patient and clinician education, to well understand and alleviate the inequalities in aspirin use and adherence. Further studies are also warranted to understand of the prescribing pattern and to provide solutions to avoid aspirin associated complications.
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