Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Effect of peripheral nerve on limb development.

F R Dietz1

  • 1Department of Orthopaedics, University of Iowa Hospitals, Iowa City 52242.

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
|January 1, 1987
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Studies of TBX4 and chromosome 17q23.1q23.2: an uncommon cause of nonsyndromic clubfoot.

American journal of medical genetics. Part A·2012
Same author

A search for the gene(s) predisposing to idiopathic clubfoot.

Clinical genetics·2005
Same author

Localization of dominantly inherited isolated triphalangeal thumb to chromosomal region 7q36.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2000
Same author

Screening for developmental dysplasia of the hip.

American family physician·1999
Same author

Long-term follow-up of Chiari pelvic osteotomy in myelomeningocele.

Journal of pediatric orthopedics·1996
Same author

Update on the genetic bases of disorders with orthopaedic manifestations.

The Journal of bone and joint surgery. American volume·1996
Same journal

Mechanical Contribution of the Anterior Talofibular Ligament to Ankle Stability: 3D Anatomical Finite Element Analysis.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2026
Same journal

Repurposing Metformin to Promote Fracture Callus Maturation via AMPK-Driven Metabolic Activation.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2026
Same journal

Biomechanical Assessment of Functional Tasks Beyond Level Walking Following Total Hip Arthroplasty: A Scoping Review.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2026
Same journal

Gait Characteristics and Intersegmental Foot and Ankle Motion in Patients With Neglected Achilles Tendon Rupture.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2026
Same journal

A Biomechanical Proof-of-Concept Study of Scaffold-Augmented Distraction Osteogenesis Using 3D-Printed Hyperelastic Bone™ in a Rabbit Tibial Lengthening Model.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2026
Same journal

Predicting Primary Stability of Stemless TSA From Preoperative Bone Density and Surgical Factors.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2026
See all related articles

Temporary nerve removal in frog limbs stunts bone and muscle growth, suggesting nerves are crucial for limb maturation. This research offers insights into growth disorders and deformities.

Area of Science:

  • Developmental biology
  • Neuroscience
  • Orthopedics

Background:

  • The role of peripheral nerves in limb development post-differentiation is understudied.
  • Nerve influence on skeletal and muscular maturation requires further investigation.

Purpose of the Study:

  • To investigate the impact of temporary denervation on limb bone and muscle development in Rana pipiens.
  • To establish a model for studying regional growth disturbances.

Main Methods:

  • Utilized Rana pipiens as an amphibian model for limb development studies.
  • Employed quantitative microscopy to assess bone and muscle size and cellularity in denervated versus control limbs.

Main Results:

  • Denervated limbs showed reduced tibial length (15%) and cross-sectional area (17%).

Related Experiment Videos

  • Tibial osteocyte density increased (26%) in denervated limbs, with no change in total osteocyte count.
  • Gastrocnemius muscle in denervated limbs exhibited decreased cross-sectional area (46%) and increased fiber density (66%).

    • Conclusions:

    • Peripheral nerve absence slows bone maturation, leading to smaller limb size.
    • Findings provide a model for understanding conditions like leg length discrepancy and deformities from paralysis.