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Antiviral agents.

P E Hermans1, F R Cockerill

  • 1Division of Infectious Diseases and Internal Medicine, Mayo Clinic, Jacksonville, Florida.

Mayo Clinic Proceedings
|December 1, 1987
PubMed
Summary
This summary is machine-generated.

This review covers key antiviral drugs. Amantadine is used for influenza A, acyclovir for herpes and varicella-zoster, ribavirin for RSV, and ganciclovir shows promise for cytomegalovirus.

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Area of Science:

  • Virology
  • Pharmacology
  • Infectious Diseases

Background:

  • Antiviral medications are crucial for managing viral infections.
  • The efficacy and application of antiviral agents vary significantly.
  • Newer drugs have replaced older treatments for certain viral conditions.

Purpose of the Study:

  • To review the current landscape of antiviral agents.
  • To highlight the specific applications and efficacies of key antiviral drugs.
  • To discuss the role of established and emerging antiviral therapies.

Main Methods:

  • Literature review of established antiviral drugs.
  • Analysis of clinical applications for influenza A, herpes simplex, varicella-zoster, respiratory syncytial virus, and cytomegalovirus.

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  • Comparison of therapeutic efficacies and current treatment standards.

    • Main Results:

    • Amantadine is the preferred agent for influenza A prophylaxis and early treatment.
    • Acyclovir is highly effective for herpes simplex and varicella-zoster virus infections, replacing vidarabine.
    • Ribavirin (aerosol) is indicated for severe respiratory syncytial virus in infants; ganciclovir shows temporary efficacy for cytomegalovirus in specific patient groups.

    Conclusions:

    • Acyclovir represents a significant advancement in treating herpes and varicella-zoster infections.
    • Ganciclovir demonstrates potential for cytomegalovirus but has limitations in certain immunocompromised populations.
    • The choice of antiviral therapy depends on the specific virus and patient condition, with ongoing research for improved treatments.