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Microneedle systems for delivering nucleic acid drugs
Inhwan Noh1, Kyuri Lee1, Yun-Seok Rhee1
1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, 501 Jinjudae-ro, Jinju, Gyeongsangnam-do 52828 Republic of Korea.
Journal of Pharmaceutical Investigation
|January 10, 2022
Summary
Microneedle systems offer a promising solution for delivering nucleic acid drugs, overcoming challenges like instability and low efficacy. This technology enhances therapeutic effectiveness, stability, and patient convenience for novel vaccination and gene therapy applications.
Area of Science:
- Investigates nucleic acid-based gene therapies and their delivery systems.
- Focuses on non-viral and physical delivery methods, including microneedle technology.
Background:
- Nucleic acid therapies show potential in vaccination and cellular reprogramming.
- Parenteral delivery faces challenges like instability and degradation.
- Microneedle systems present a minimally invasive alternative for enhanced nucleic acid delivery.
Purpose of the Study:
- To review the current status and features of nucleic acid medicines.
- To explore delivery systems for nucleic acid drugs, emphasizing microneedles.
- To highlight recent advancements in microneedle-based nucleic acid drug delivery, including vaccination.
Main Methods:
- Literature review of nucleic acid medicines and delivery systems.
- Examination of non-viral and physical delivery methods.
- Analysis of microneedle types, properties, and applications.
Main Results:
- Nucleic acid drugs offer advantages over conventional small molecules.
- Microneedle delivery enhances nucleic acid drug efficacy and stability.
- Recent advances show potential in vaccination applications.
Conclusions:
- Microneedle-mediated delivery is a viable strategy for nucleic acid drugs.
- This approach improves stability, efficacy, and patient experience.
- Nucleic acid therapies, particularly via microneedles, are crucial for future medicine.
