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Updated: Oct 7, 2025
11:36
Glycan Node Analysis: A Bottom-up Approach to Glycomics
Published on: May 22, 2016
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Glycosylation Changes in Prostate Cancer Progression
William Butler1, Jiaoti Huang1
1Department of Pathology, Duke University School of Medicine, Durham, NC, United States.
Frontiers in Oncology
|January 10, 2022
Summary
Altered glycosylation patterns in prostate cancer (PCa) offer promising new biomarkers for diagnosis and risk stratification. Understanding these glycan changes can improve early detection and treatment strategies for men with PCa.
Area of Science:
- Biochemistry
- Oncology
- Glycomics
Background:
- Prostate cancer (PCa) is a leading cause of cancer death in men.
- Altered glycosylation is a recognized hallmark of cancer progression.
- Glycans show potential as diagnostic and prognostic biomarkers for PCa.
Purpose of the Study:
- To review findings on altered glycosylation in PCa tissue and body fluids.
- To discuss changes in O-GlcNAcylation, galectins, and glycoconjugates in PCa.
- To emphasize the clinical utility of glycans as biomarkers and therapeutic targets.
Main Methods:
- Review of studies on N- and O-linked glycosylation in PCa.
- Analysis of O-GlcNAcylation alterations.
- Examination of galectin and glycoconjugate expression in PCa.
Main Results:
- PCa exhibits diverse glycan alterations, including sialylation, fucosylation, and Lewis antigen changes.
- Emergence of high mannose structures and aberrant expression of galectins/glycolipids are noted.
- Glycosylation changes impact PCa cell survival, metastasis, and immunogenicity.
Conclusions:
- Altered glycosylation is a significant feature of prostate cancer.
- Glycans hold promise for improved PCa diagnosis, risk stratification, and targeted therapies.
- Exploiting glycan biomarkers can enhance clinical management of PCa.
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