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Extensive Giant Tuberous and Tendon Xanthomas in a 48-year-old Gentleman: A Case Report
Jagandeep S Virk1, Divya Arora2, Poonam Bhaker3
1Department of Orthopaedic Oncology, Paras Hospitals, Panchkula, Haryana, India.
Journal of Orthopaedic Case Reports
|January 10, 2022
Summary
This case report details a rare instance of co-existing tuberous and tendinous xanthomas in a patient with familial hypercholesterolemia. Early intervention is crucial for managing these lipid disorders and preventing disfiguring lesions.
Area of Science:
- Dermatology and Endocrinology
- Lipid Metabolism Disorders
Background:
- Xanthomas are benign lesions caused by lipid-laden macrophages in subcutaneous tissue.
- Classified by location (eruptive, tuberous, tendinous, planar).
- Co-existence of tuberous and tendinous xanthomas is rare.
Observation:
- A 48-year-old male presented with large xanthomas on elbows, knees, and tendons.
- Elevated low-density lipoprotein cholesterol confirmed Type IIa familial hypercholesterolemia.
- Largest masses measured 12 cm x 10 cm.
Findings:
- Diagnosis of multiple, large, co-existing tuberous and tendinous xanthomas.
- Histological analysis confirmed xanthoma diagnosis.
- Surgical excision of symptomatic masses was performed.
Implications:
- Highlights the possibility of atypical large xanthomas co-existing.
- Underscores the need for cardiology workup in xanthoma patients.
- Early intervention can prevent disfiguring xanthomas and manage lipid disorders.
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