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A Systematic Review and Recommendations Around Frameworks for Evaluating Scientific Validity in Nutritional Genomics
Justine Keathley1,2,3,4,5,6, Véronique Garneau1,2, Daniela Zavala-Mora7
1Centre Nutrition, Santé et Société (NUTRISS), Institut sur la Nutrition et les Aliments Fonctionnels (INAF), Université Laval, Québec City, QC, Canada.
Frontiers in Nutrition
|January 10, 2022
Summary
A systematic review identified an optimal framework for evaluating nutrigenetic research validity. Minor modifications can further enhance its rigor for assessing nutritional genomics studies.
Area of Science:
- Nutrigenetics
- Genetics
- Nutrition Science
Background:
- Inconsistent methods exist for assessing the scientific validity of nutrigenetic research.
- This study aimed to identify and evaluate existing frameworks for scientific validity in nutrition and genetics.
Approach:
- Conducted a systematic review of literature up to July 2021, screening 3,931 articles.
- Identified 41 frameworks used in genetics, nutrition, or both, assessing their components and applicability to nutrigenetics.
- Critically appraised frameworks using a matrix of key factors important for nutrigenetic validity.
Key Points:
- Identified critical factors for nutrigenetic validity: study design, generalizability, biological plausibility, dose-response, and bias.
- Most frameworks assessed study quality, but few considered dose-response effects.
- Two frameworks nearly met all predetermined criteria for nutrigenetic scientific validity.
Conclusions:
- One existing framework is optimal for evaluating scientific validity in nutritional genomics.
- Minor modifications to this framework are proposed to enhance its rigor for nutrigenetic research.
Keywords:
clinical practiceframeworksgeneticsnutrigenetics/nutrigenomicsnutritionnutritional genomicsscientific validitysystematic reviewMore Related Videos
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