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Updated: Oct 7, 2025
Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release
Published on: June 12, 2021
Enhanced visibility through microbubble-induced photoacoustic fluctuation imaging
Marco A Inzunza-Ibarra1, J Angel Navarro-Becerra1, Venkatalakshmi Narumanchi2
1Department of Mechanical Engineering, University of Colorado, Boulder, Colorado 80309, USA.
Abstract:
A photoacoustic contrast mechanism is presented based on the photoacoustic fluctuations induced by microbubbles flowing inside a micro-vessel filled with a continuous absorber. It is demonstrated that the standard deviation of a homogeneous absorber mixed with microbubbles increases non-linearly as the microbubble concentration and microbubble size is increased. This effect is then utilized to perform photoacoustic fluctuation imaging with increased visibility and contrast of a blood flow phantom.
