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Selectively disrupted sensorimotor circuits in chronic stroke with hand dysfunction.

FeiWen Liu1, ChangCheng Chen2, WenJun Hong3

  • 1Department of Rehabilitation Medicine, Chengdu Second People's Hospital, Chengdu, China.

CNS Neuroscience & Therapeutics
|January 10, 2022
PubMed
Summary
This summary is machine-generated.

Sensorimotor cortex (SMC) neurocircuitry is selectively disrupted after stroke, impacting hand function. Connectivity patterns differ between partially and completely paretic hands, offering insights into sensorimotor reorganization.

Keywords:
Granger causality analysiseffective connectivityfunctional reorganizationresting-state functional magnetic resonance imagingstroke

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Area of Science:

  • Neuroscience
  • Neuroimaging
  • Rehabilitation Medicine

Background:

  • Stroke often leads to sensorimotor cortex (SMC) dysfunction, resulting in hand impairment.
  • Understanding the specific disruptions in SMC subregions and their connectivity is crucial for effective rehabilitation.

Purpose of the Study:

  • To investigate the directional and selective disconnection of sensorimotor cortex (SMC) subregions in chronic stroke patients with hand dysfunction.
  • To correlate effective connectivity (EC) patterns with paretic hand performance.

Main Methods:

  • Resting-state fMRI was used to map EC patterns in seven SMC subregions across both hemispheres.
  • Data were collected from 65 chronic stroke patients and 40 healthy controls.
  • Connectivity patterns were correlated with paretic hand motor function.

Main Results:

  • Stroke patients showed disrupted EC in ipsilesional primary motor cortex, ipsilesional primary somatosensory cortex (PSC_2), and contralesional PSC_3a compared to controls.
  • Specific EC pathways correlated with paretic hand performance across all patients.
  • Partially paretic hand patients exhibited decreased EC in ipsilesional premotor_6 and ipsilesional PSC_1 compared to completely paretic hand patients.

Conclusions:

  • Sensorimotor cortex neurocircuitry is selectively disrupted post-stroke, correlating with varying hand function outcomes.
  • These findings deepen the understanding of SMC reorganization and its association with motor deficits.