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Related Experiment Video

Updated: Jun 24, 2026

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Published on: July 1, 2013

Multifunctional Titanium Surfaces for Orthopedic Implants: Antimicrobial Activity and Enhanced Osseointegration.

Fiorela Ghilini¹, Natalia Fagali¹, Diego E Pissinis¹

¹Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), Facultad de Ciencias Exactas, UNLP - CONICET, CC16 Suc 4, 1900 La Plata, Buenos Aires, Argentina.

ACS Applied Bio Materials

|January 10, 2022

Summary

This study developed a novel coating for titanium implants using silver nanoparticles and lactoferrin. The coating enhances bone growth and significantly reduces bacterial infection, improving implant success rates.

Keywords:

Ti implants antibacterial lactoferrin multifunctional surfaces osseointegration silver nanoparticles

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Last Updated: Jun 24, 2026

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

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Published on: July 1, 2013

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Plasma Polishing as a New Polishing Option to Reduce the Surface Roughness of Porous Titanium Alloy for 3D Printing

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Published on: April 28, 2023

Area of Science:

Biomaterials Science
Nanotechnology
Orthopedic Surgery
Dental Implantology

Background:

Metallic implants are widely used in orthopedics and dentistry.
Peri-implantitis and poor osseointegration can lead to implant failure.
Existing treatments often fail to address both infection and regeneration simultaneously.

Purpose of the Study:

To develop a multifunctional coating for titanium (Ti) surfaces.
To combine antibacterial silver nanoparticles (AgNPs) and regenerative lactoferrin (Lf).
To simultaneously address infection and improve osseointegration of medical implants.

Main Methods:

A simple, cost-effective method for direct multifunctionalization of Ti surfaces.
Characterization using atomic force microscopy (AFM), X-ray photoelectron spectroscopy, and contact angle measurements.
In vitro evaluation of preosteoblast cell adhesion, viability, differentiation, and antibacterial activity against Staphylococcus aureus.

Main Results:

Lactoferrin (Lf) successfully adsorbed onto Ti surfaces with and without AgNPs.
The Lf and AgNPs coating significantly improved preosteoblast adhesion, proliferation, and differentiation.
Bacterial colonization was reduced by 97.7% compared to uncoated surfaces.

Conclusions:

The developed multifunctional coating shows potential for medical devices.
This approach can simultaneously enhance osseointegration and reduce bacterial infection risk.
The method offers a promising strategy for improving implant success and patient quality of life.