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Related Concept Videos

Proteomics01:33

Proteomics

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Corrigendum to 'Salivary responses to an experimental activation of the HPA axis in pigs: Effects of ACTH on analytes related to stress, immune system, inflammation, redox status and metabolism' [Veterinary And Animal Science 32 (2026)100650].

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Related Experiment Video

Updated: Oct 7, 2025

Comprehensive Workflow of Mass Spectrometry-based Shotgun Proteomics of Tissue Samples
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Proteomics in dogs: a systematic review.

Luis Guillermo González-Arostegui1, Camila Peres Rubio2, José Joaquín Cerón1

  • 1Interdisciplinary Laboratory of Clinical Analysis (Interlab-UMU), Veterinary School, Campus of Excellence Mare Nostrum, University of Murcia, Campus Espinardo, 30100 Murcia, Spain.

Research in Veterinary Science
|January 10, 2022
PubMed
Summary

Proteomic analysis in dogs is rapidly advancing for disease biomarker discovery. This review highlights key findings from studies on canine serum and saliva proteomes, identifying new disease pathways.

Keywords:
AnimalsBiomarkersDogsProteinsProteomics

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Area of Science:

  • Veterinary proteomics
  • Biomarker discovery in companion animals

Background:

  • Dogs are vital companion animals and serve as important models in biomedical research.
  • Proteomic analysis offers a powerful approach for identifying disease biomarkers in dogs.

Purpose of the Study:

  • To systematically review published studies on canine proteomics, focusing on serum, saliva, urine, and plasma.
  • To assess the current state and potential of proteomic analysis for canine disease research.

Main Methods:

  • Systematic literature review of English-language publications from 2010-2020.
  • Searches conducted in October 2020, January 2021, and August 2021.
  • Screening, data extraction, and risk of bias assessment performed by two investigators; meta-analyses and case reports excluded.

Main Results:

  • 44 studies were included after screening 557 publications.
  • Most studies compared disease and healthy canine populations, primarily using serum and saliva.
  • A high overall risk of bias was noted, mainly due to a lack of random sequence generation.

Conclusions:

  • Proteomic analysis in dogs has successfully identified novel physiopathological pathways and potential disease biomarkers.
  • Further research with robust methodologies is needed to fully leverage canine proteomics for veterinary medicine.