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Changes in serum CK-MB mass after coronary artery bypass surgery
F Van Lente1, A M McHugh, R S Galen
1Department of Biochemistry, Cleveland Clinic Foundation, Ohio 44106.
Clinical Biochemistry
|October 1, 1987
Summary
Cardiac surgery patients showed significant release of creatine kinase-MB (CK-MB) mass and activity post-operation. CK-MB mass strongly correlated with CK-MB activity, indicating its reliability in assessing cardiac muscle damage after surgery.
Area of Science:
- Biochemistry
- Cardiology
- Clinical Chemistry
Background:
- Cardiac surgery can lead to myocardial injury, necessitating reliable biomarkers for assessment.
- Creatine kinase-MB (CK-MB) is a key indicator of cardiac muscle damage.
- Evaluating both CK-MB mass and activity is crucial for understanding its release kinetics.
Purpose of the Study:
- To assess the release patterns of CK-MB mass and activity in the postoperative period after cardiac surgery.
- To compare CK-MB mass and activity measurements with other cardiac biomarkers and surgical parameters.
- To determine the correlation between CK-MB mass and activity and their relationship with surgical variables.
Main Methods:
- Enzyme immunoassay for CK-MB mass and agarose electrophoresis/immunochemical methods for CK-MB activity.
- Serial serum sample collection from 55 cardiac surgery patients and 52 orthopedic surgery controls.
- Measurement of total LD, CK, AST, LD-1, CK-MB mass, and CK-MB activity.
Main Results:
- All cardiac surgery patients exhibited significant postoperative CK-MB mass and activity.
- CK-MB mass showed a strong correlation with CK-MB activity (r = 0.94).
- Peak CK-MB mass correlated significantly with peak MB activity, LD-1, AST, and time on pump.
Conclusions:
- CK-MB mass is a reliable indicator of cardiac muscle release following cardiac surgery.
- The release kinetics of CK-MB mass closely mirror those of CK-MB activity.
- CK-MB mass measurements provide valuable insights into myocardial stress during the postoperative phase.