Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

4.8K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
4.8K
Cell Polarization by Rho Proteins01:21

Cell Polarization by Rho Proteins

2.9K
Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...
2.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synergistic and Selective Antiproliferative Effects of Cafestol and a Hyaluronic Acid-Epigallocatechin Gallate Conjugate in Human Renal Cancer Cells.

International journal of molecular sciences·2026
Same author

Fibroblast-mediated KRAS activation in double-negative prostate cancer.

Cell death & disease·2026
Same author

Urethral Closure Mechanism Caused by Prostate Rotation During Abdominal Pressure in Men: A Dynamic Magnetic Resonance Imaging Study.

Neurourology and urodynamics·2026
Same author

A Minimum 3-Year Follow-Up of Nivolumab-Plus-Ipilimumab in Japanese Patients With Advanced or Metastatic Renal Cell Carcinoma: A Final Analysis of the J-ENCORE Study.

International journal of urology : official journal of the Japanese Urological Association·2026
Same author

High-Dose-Rate Brachytherapy Combined with External Beam Radiotherapy for Newly Defined Very High-Risk and Regional Prostate Cancer: A 17-Year Single-Institution Experience.

Cancers·2026
Same author

Post Hoc Subgroup Analysis of Clinical Outcomes in Patients With High-Risk Metastatic Hormone-Naïve Prostate Cancer: Results From a 3-Year Interim Analysis of the J-ROCK Study.

The Prostate·2026

Related Experiment Video

Updated: Oct 7, 2025

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages
10:07

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages

Published on: June 23, 2013

67.1K

Macrophage Polarity and Disease Control.

Suguru Kadomoto1, Kouji Izumi1, Atsushi Mizokami1

  • 1Department of Integrative Cancer Therapy and Urology, Graduate School of Medical Science, Kanazawa University, 13-1 Takaramachi, Kanazawa 920-8641, Japan.

International Journal of Molecular Sciences
|January 11, 2022
PubMed
Summary

Macrophages, crucial immune cells, exist as M1 and M2 phenotypes influencing health and disease. Understanding macrophage polarity is key for developing new treatments for infections, inflammation, and cancer.

Keywords:
M1M2autoimmune diseasescell-cell interactionmicroenvironmentmonocytestumor-associated macrophages

More Related Videos

Macrophage Differentiation and Polarization into an M2-Like Phenotype using a Human Monocyte-Like THP-1 Leukemia Cell Line
06:38

Macrophage Differentiation and Polarization into an M2-Like Phenotype using a Human Monocyte-Like THP-1 Leukemia Cell Line

Published on: August 2, 2021

29.3K
Reprograming Model of Human Monocyte-derived Macrophages for In-vitro Assays
08:37

Reprograming Model of Human Monocyte-derived Macrophages for In-vitro Assays

Published on: April 18, 2025

594

Related Experiment Videos

Last Updated: Oct 7, 2025

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages
10:07

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages

Published on: June 23, 2013

67.1K
Macrophage Differentiation and Polarization into an M2-Like Phenotype using a Human Monocyte-Like THP-1 Leukemia Cell Line
06:38

Macrophage Differentiation and Polarization into an M2-Like Phenotype using a Human Monocyte-Like THP-1 Leukemia Cell Line

Published on: August 2, 2021

29.3K
Reprograming Model of Human Monocyte-derived Macrophages for In-vitro Assays
08:37

Reprograming Model of Human Monocyte-derived Macrophages for In-vitro Assays

Published on: April 18, 2025

594

Area of Science:

  • Immunology
  • Cell Biology
  • Pathophysiology

Background:

  • Macrophages are ubiquitous immune cells with diverse functions in human tissues.
  • Activated macrophages differentiate into distinct phenotypes, primarily M1 and M2.
  • Macrophage polarization is influenced by microorganisms, tissue microenvironments, and cytokine signaling.

Purpose of the Study:

  • To review the current understanding of macrophage polarity.
  • To explore the significance of macrophage polarity in various diseases.
  • To assess macrophage polarity as a potential therapeutic target.

Main Methods:

  • Literature review of studies on macrophage activation and polarization.
  • Analysis of factors influencing M1/M2 macrophage phenotypes.
  • Evaluation of the role of macrophage polarity in disease pathogenesis.

Main Results:

  • Macrophage polarity is critical for immune responses, inflammation, and cancer progression.
  • Dysregulation of macrophage polarization is implicated in various pathological conditions.
  • Specific factors significantly modulate macrophage phenotypes.

Conclusions:

  • Macrophage polarity is a key determinant of immune homeostasis and disease outcomes.
  • Targeting macrophage polarization offers promising therapeutic strategies for infections, inflammatory diseases, and malignancies.
  • Further research into macrophage polarity could unlock novel treatment avenues.