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The YAP/TAZ Signaling Pathway in the Tumor Microenvironment and Carcinogenesis: Current Knowledge and Therapeutic

Ángel Ortega1, Ivana Vera1, Maria P Diaz1

  • 1Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela.

International Journal of Molecular Sciences
|January 11, 2022
PubMed
Summary

The yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are key in cell growth and cancer. YAP/TAZ pathway dysregulation drives tumor progression and resistance to therapies.

Keywords:
Hippo signaling pathwayTEADYAP/TAZcarcinogenesiscell proliferationchemoresistancedrug resistanceimmunotherapyneoplastic stem cellstumor microenvironment

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