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[Intracamera penetration of ofloxacin in man]
Abstract:
The authors have studied the penetration of Ofloxacin in the aqueous humour in 30 patients (30 eyes). Six hours after a single oral dose of 200 mg, the concentration in the anterior chamber reached 0.6 microgram/ml which is 23% of the average serum level. It is over the minimal inhibitory concentration necessary for many bacterial agents found in endophthalmitis (except Streptococcus) because the MIC of Ofloxacin are the lowest among quinolones. Side effects and association with other antibiotics are precise.
Insights
Ofloxacin effectively penetrates the aqueous humor after oral administration, reaching concentrations above the minimum inhibitory level for many common bacterial eye infections. This study highlights its potential therapeutic value in treating endophthalmitis.
Area of Science:
- Ophthalmology
- Pharmacokinetics
- Microbiology
Context:
- Endophthalmitis is a severe intraocular infection requiring prompt treatment.
- Understanding drug penetration into the anterior chamber is crucial for effective therapy.
Purpose:
- To evaluate the penetration of Ofloxacin into the aqueous humor following oral administration.
- To determine the concentration of Ofloxacin in the anterior chamber and compare it to serum levels and minimum inhibitory concentrations.
Summary:
- A single 200 mg oral dose of Ofloxacin resulted in an anterior chamber concentration of 0.6 microgram/ml, representing 23% of the average serum level.
- This concentration exceeds the minimum inhibitory concentration (MIC) for many bacteria implicated in endophthalmitis, excluding Streptococcus.
- Ofloxacin exhibits the lowest MIC among quinolones, suggesting broad-spectrum antibacterial activity.
Impact:
- The findings support the potential use of oral Ofloxacin for treating bacterial endophthalmitis.
- Further research may explore Ofloxacin's efficacy in combination with other antibiotics.