Carbon Dioxide Sensing-Biomedical Applications to Human Subjects

Area of Science:

• Medical Devices
• Biomedical Engineering
• Analytical Chemistry

Background:

• Transcutaneous carbon dioxide (CO2) monitoring is crucial for human subjects in medical practice.
• Current Stow-Severinghaus electrode-based monitors are expensive, bulky, and prone to drift, necessitating frequent recalibration.

Purpose of the Study:

• To thoroughly review existing CO2 measurement techniques.
• To identify potential alternatives for developing future non-invasive clinical CO2 monitors.

Main Methods:

• Comprehensive review of various CO2 sensing techniques.
• Analysis of physicochemical working principles, merit criteria, advantages, and drawbacks.
• Evaluation of clinical constraints and specificities of current monitoring methods.

Main Results:

• Existing transcutaneous CO2 monitors have significant limitations.
• Dye-based fluorescence CO2 sensing demonstrates potential for non-invasive monitoring.

Conclusions:

• Transcutaneous sensing combined with dye-based fluorescence CO2 sensing shows the most promise for future non-invasive clinical CO2 monitoring.
• This approach could overcome the limitations of current technologies.