Exercise Performance Upregulatory Effect of R-α-Lipoic Acid with γ-Cyclodextrin

Area of Science:

• Biochemistry
• Exercise Physiology
• Nutraceutical Science

Background:

• Alpha-lipoic acid (ALA) is a vital enzyme cofactor with optical isomers, RALA and SALA.
• R-alpha-lipoic acid (RALA) is crucial for energy metabolism but unstable under heat and acid conditions.
• Complexing RALA with gamma-cyclodextrin (CD) enhances its antioxidant capacity and stability.

Purpose of the Study:

• To investigate the impact of gamma-cyclodextrin complexed with R-alpha-lipoic acid (CD/RALA) on antioxidant activity.
• To evaluate the effect of CD/RALA supplementation on exercise performance during high-intensity exercise.

Main Methods:

• Twenty-four male mice were divided into four groups: control (swimming+water), CD/RALA, RALA, and CD.
• Mice underwent high-intensity swimming exercise protocols.
• Blood ammonia levels and kidney oxidative stress markers were measured post-exercise.

Main Results:

• CD/RALA supplementation significantly repressed exercise-induced blood ammonia elevation.
• Oxidative stress in the kidney, increased by exercise, was reduced by CD/RALA supplementation.
• Free RALA and CD supplementation did not show the same protective effects.

Conclusions:

• CD/RALA complex supplementation demonstrates potential in mitigating exercise-induced oxidative stress.
• This formulation may offer benefits for improving athletic performance and aiding recovery in athletes.