[Etiology and pathogenesis of internal root resorption]

Area of Science:

• Endodontics
• Dental Pathology

Background:

• Internal root resorption is characterized by intraradicular dentin destruction due to odontoclast activity.
• Its insidious nature often leads to delayed clinical detection.
• The precise etiology, natural history, and molecular pathogenesis remain incompletely understood.

Purpose of the Study:

• To review the current understanding of the etiology and pathogenesis of internal root resorption.
• To provide guidance for early clinical intervention.

Main Methods:

• Literature review of internal root resorption.
• Analysis of proposed etiological factors and pathogenetic mechanisms.

Main Results:

• Resorption initiation involves stimuli leading to predentin loss.
• Pulp infection acts as a continuous stimulus for progression.
• Proposed etiological factors include trauma, pulp inflammation, pulpotomy, and tooth transplantation.

Conclusions:

• Internal root resorption is a complex pathological process.
• Further research into molecular pathogenesis is needed.
• Early intervention strategies are essential for managing this condition.