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Interfacial-confined coordination to single-atom nanotherapeutics.

Limei Qin1, Jie Gan2, Dechao Niu3

  • 1Lab of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine Materials of Ministry of Education, Frontier Science Center of the Materials Biology and Dynamic Chemistry, Shanghai Engineering Research Center of Hierarchical Nanomaterials, School of Materials Science and Engineering, East China University of Science and Technology, 200237, Shanghai, China.

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Researchers developed a new single-atom nanotherapeutic using iron atoms on carbon dots within silica nanoreactors. This advanced material shows high efficiency for tumor therapy, offering a promising new strategy.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Developing efficient catalytic sites for enhanced atomic and energy efficiency via material engineering is crucial.
  • Bio-applicable single-atom materials lag behind carbon-based systems in research.
  • There is a need for advanced nanotherapeutics for efficient tumor treatment.

Purpose of the Study:

  • To propose a facile strategy for constructing high-quality single-atom nanotherapeutic agents.
  • To demonstrate the energy conversion capability of silica-based single-atom systems.
  • To provide a paradigm for designing versatile single-atom nanotherapeutics for tumor therapy.

Main Methods:

  • An interfacial-confined coordination strategy was employed to anchor Fe single atoms onto defective carbon dots.
  • These Fe-loaded carbon dots were confined within a biocompatible mesoporous silica nanoreactor.
  • Density Functional Theory (DFT) calculations were used to investigate the mechanism of photothermal conversion.

Main Results:

  • High-quality single-atom nanotherapeutic agents with Fe single atoms anchored on defective carbon dots were successfully constructed.
  • The silica-based Fe single-atom system exhibited efficient energy conversion under both photo irradiation and reactive oxygen species stimulus.
  • The highest photothermal conversion efficiency was achieved, attributed to increased electron density and a narrow bandgap, as confirmed by DFT calculations.

Conclusions:

  • The developed interfacial-confined coordination strategy is a facile and general method for creating advanced single-atom nanotherapeutics.
  • The Fe single-atom nanotherapeutic agent demonstrates significant potential for safe and efficient tumor therapy.
  • This work provides a scientific framework for designing tunable single-atom nanotherapeutics with adjustable metal components for various therapeutic applications.