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Development of Inspired Therapeutics Pediatric VAD: Computational Analysis and Characterization of VAD V3

Landon H Tompkins1, Barry N Gellman2, Steven R Prina3

  • 1Department of Bioengineering, University of Louisville, Louisville, KY, 40202, USA.

Cardiovascular Engineering and Technology
|January 11, 2022
PubMed

Insights

The Inspired Pediatric VAD V3 shows promising computational results for pediatric heart failure patients needing mechanical circulatory support. This device aims to improve blood flow and minimize damage, with further testing planned.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Technology

Background:

  • Pediatric heart failure patients require specialized mechanical circulatory support (MCS) devices.
  • Current MCS development primarily focuses on adults, leaving a critical gap for pediatric solutions.
  • The Inspired Pediatric VAD is engineered as a compact, modular MCS for up to 30-day support, potentially enabling ambulation.

Purpose of the Study:

  • To computationally evaluate the hydrodynamic performance and blood compatibility of the Inspired Pediatric VAD V3.
  • To assess impeller/rotor mechanical properties and flow characteristics under various operating conditions.

Main Methods:

  • Utilized computational fluid dynamics (CFD) with SolidWorks Flow Simulator to analyze the Inspired Pediatric VAD V3.
  • Investigated hydrodynamic performance, including flows and pressures.
  • Evaluated impeller/rotor torques, forces, shear stress, and residence time distributions.

Main Results:

  • The V3 design maintained comparable flow and pressure head to the V2 design.
  • Improved geometry resulted in increased impeller/rotor torques and translation forces.
  • Analysis showed low percentages of pump volume exposed to high shear stress ranges associated with blood damage (<1% at 150-1000 Pa at lowest operating point, 2.3% at higher operating point).

Conclusions:

  • Initial computational characterization of the Inspired Pediatric VAD V3 is encouraging.
  • The device demonstrates potential for safe and effective pediatric mechanical circulatory support.
  • Future research will involve prototype testing in mock circulatory loops and animal models.
Abstract

Keywords:
Centrifugal pumpComputational fluid dynamicsHeart failureImpellerMagLevMagnetic levitationMechanical circulatory supportPediatricRotary blood pumpVAD

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