Parkinson's Disease and Ischemic Stroke: a Bidirectional Mendelian Randomization Study
Shiyuan Fang1,2, Xinzhi Hu2, Tao Wang1,3
1Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
Translational Stroke Research
|January 11, 2022
Summary
Parkinson's disease (PD) may cause ischemic stroke (IS), particularly cardioembolic and large artery subtypes. Genetic analysis found no evidence that IS causes PD or affects small-vessel stroke.
Area of Science:
- Neurology
- Genetics
- Epidemiology
Background:
- Parkinson's disease (PD) and ischemic stroke (IS) are significant global health concerns.
- Understanding the etiological relationship between PD and IS is crucial for effective prevention and treatment strategies.
Purpose of the Study:
- To investigate the potential causal relationship between Parkinson's disease and ischemic stroke using Mendelian randomization.
- To determine if PD is a causal factor for IS and its subtypes, and to assess for reverse causality.
Main Methods:
- Utilized Mendelian randomization (MR) methods with summary statistics from large-scale genome-wide association studies (GWAS).
- Included 33,674 PD cases and 40,585 IS cases.
- Employed inverse variance-weighted, weighted median, MR-Egger, robust adjusted profile score, and radial regression methods for primary and sensitivity analyses, including bidirectional analyses.
Main Results:
- Primary analysis indicated a significant causal association between PD and IS (OR 1.04, p=0.0019).
- PD was found to be a potential cause of cardioembolic stroke (OR 1.11, p=0.0001) and large artery stroke (OR 1.08, p=0.034), but not small-vessel stroke (p=0.180).
- Sensitivity analyses supported these findings, and no strong evidence for reverse causality from IS to PD was observed.
Conclusions:
- Parkinson's disease is a potential causal factor for cardioembolic and large artery ischemic stroke.
- There is no significant evidence that ischemic stroke causes Parkinson's disease.
- These findings highlight a potential etiological link between PD and specific IS subtypes, informing future research and clinical considerations.
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