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Fluorescent Carbon Nano-onion as Bioimaging Probe.
Chumki Dalal1, Deepika Saini1, Anjali Kumari Garg1
1Department of Chemistry, Malaviya National Institute of Technology, Jaipur, Jaipur 302017, India.
ACS Applied Bio Materials
|January 11, 2022
Summary
Carbon nano-onions (CNOs) are versatile for bioimaging. This review covers their synthesis, fluorescence, and biocompatibility for advanced in vitro and in vivo applications.
Area of Science:
- Nanotechnology
- Biomedical Imaging
- Materials Science
Background:
- Carbon nano-onions (CNOs) are concentric, onion-like fullerene structures.
- CNOs offer potential in bioimaging due to their unique morphology and low cytotoxicity.
- They are structurally similar to multiwalled carbon nanotubes but with enhanced biological compatibility.
Purpose of the Study:
- To review the synthesis and surface functionalization of CNOs.
- To elucidate the origin of fluorescence in CNO-based nanoprobes (Type I and Type II).
- To summarize recent advancements in CNO applications for in vitro and in vivo bioimaging.
Main Methods:
- Review of literature on CNO synthesis and functionalization techniques.
- Analysis of fluorescence mechanisms in CNO nanoprobes.
- Compilation of data from in vitro and in vivo imaging studies using CNOs.
Main Results:
- CNOs can be functionalized to create Type I (requiring external moieties) or Type II (intrinsic fluorescence) nanoprobes.
- CNOs exhibit low cytotoxicity, enabling prolonged use in biological systems.
- Demonstrated utility of CNOs in various in vitro and in vivo imaging studies.
Conclusions:
- CNOs are promising nanomaterials for bioimaging applications.
- Understanding fluorescence origins and optimizing biocompatibility are key for CNO development.
- Further research into CNOs will advance in vitro and in vivo imaging techniques.
