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Engineering Carbohydrate-Based Particles for Biomedical Applications: Strategies to Construct and Modify.

Aiswarya Thattaru Thodikayil1, Shivangi Sharma1, Sampa Saha1

  • 1Department of Materials Science and Engineering, Indian Institute of Technology Delhi, New Delhi 110016, India.

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|January 11, 2022
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Summary

Carbohydrate-based nanoparticles offer biocompatible and non-toxic solutions for drug delivery and bioimaging. This review highlights recent synthetic methods for these advanced carbohydrate particles and their biomedical applications.

Keywords:
biocompatibilitybioimagingcarbohydrate-based nanoparticleslectin bindingtargeted drug delivery

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery

Background:

  • Carbohydrate-based micro/nanoparticles are gaining traction in biomedicine due to excellent biocompatibility, biodegradability, and low toxicity.
  • Their ability to target specific cell surface receptors makes them ideal for targeted drug delivery systems.
  • These particles can be purely carbohydrate-based or hybrids with inorganic nanoparticles to enhance cellular uptake and reduce toxicity.

Purpose of the Study:

  • To review recently developed synthetic approaches for carbohydrate-based and carbohydrate-conjugated nanoparticles.
  • To highlight the significance and diverse biomedical applications of these advanced carbohydrate particles.

Main Methods:

  • Literature review of synthetic methodologies for carbohydrate-based micro/nanoparticles.
  • Analysis of applications in drug delivery, bioimaging, and biosensing.

Main Results:

  • Various synthetic strategies have been established for fabricating carbohydrate micro/nanoparticles.
  • These particles demonstrate significant potential in targeted drug delivery, bioimaging, and biosensing applications.
  • Hybrid nanoparticles combining carbohydrates with inorganic materials show promise for improved cellular insertion and reduced toxicity.

Conclusions:

  • Carbohydrate-based nanoparticles represent a versatile platform for advanced biomedical applications.
  • Continued development of synthetic methods will further unlock their therapeutic and diagnostic potential.
  • These materials are crucial for the future of targeted and controlled therapeutic delivery systems.