Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fiber-Optic Quantum Dots Sensor for Dynamic and Quantitative Thermal Monitoring of Spheroids toward Single-Cellular Resolution.

ACS nano·2026
Same author

Celastrol Suppresses Porcine Deltacoronavirus Replication by Modulating Endoplasmic Reticulum Stress-Associated Ca<sup>2+</sup> Balance.

Transboundary and emerging diseases·2026
Same author

Notoginsenoside R1 Inhibits Porcine Deltacoronavirus Infection In Vitro by Restoring SERCA2-Mediated Calcium Homeostasis.

Animals : an open access journal from MDPI·2026
Same author

Spatially resolved profiling of extracellular vesicles in tissues with Spatial-EV-seq.

Nature biotechnology·2026
Same author

Cyclic transformation of stable/metastable nucleic acid structures enables dynamic monitoring of ATP in living cells.

Chemical science·2026
Same author

Body mass index moderates the effects of midsole hardness on metatarsophalangeal joint biomechanics during running in male recreational runners.

Journal of biomechanics·2026
Same journal

Bioorthogonal Click Chemistry Engineered Bioinks for 3D Bioprinting in Osteochondral Regeneration and Osteoarthritis Therapy: A Translational Review.

ACS applied bio materials·2026
Same journal

Green Composite of Banana Powder and Graphite-Incorporated PANI Deposited on Cotton Fabric with Enhanced Humidity Sensitivity.

ACS applied bio materials·2026
Same journal

Bioactive Peptides for Oral Diseases: Biomaterial-Assisted Therapeutics and Translational Applications.

ACS applied bio materials·2026
Same journal

Click-Chemistry-Based Antibacterial Hybrid Hydrogel with Sustained Puerarin Release for Diabetic Wound Healing.

ACS applied bio materials·2026
Same journal

Nanotechnology in Plastic and Reconstructive Surgery: Emerging Innovations in Wound Healing, Aesthetic Applications, and Skin Regeneration.

ACS applied bio materials·2026
Same journal

Therapeutic Vaccines Based on Iron-Coordinated Metal-Phenolic Networks for Eradicating Drug-Resistant Staphylococcus aureus.

ACS applied bio materials·2026
See all related articles

Related Experiment Video

Updated: Oct 7, 2025

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications
05:26

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications

Published on: September 16, 2022

4.2K

Recent Advances in Aptamer-Based Liquid Biopsy.

Jialu Zhang1, Yihao Huang1, Miao Sun1

  • 1The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.

ACS Applied Bio Materials
|January 11, 2022
PubMed
Summary
This summary is machine-generated.

Aptamers offer precise, noninvasive liquid biopsy for detecting extracellular vesicles (EVs) and circulating tumor cells (CTCs). This review highlights aptamer-based strategies for improved cancer diagnosis and patient monitoring.

Keywords:
aptamercirculating tumor cellsextracellular vesiclesliquid biopsyselection

More Related Videos

Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients
08:25

Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients

Published on: September 9, 2020

11.3K
Automatic Separation and Collection of Cancer-Related Substances from Clinical Samples
08:49

Automatic Separation and Collection of Cancer-Related Substances from Clinical Samples

Published on: January 13, 2023

2.0K

Related Experiment Videos

Last Updated: Oct 7, 2025

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications
05:26

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications

Published on: September 16, 2022

4.2K
Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients
08:25

Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients

Published on: September 9, 2020

11.3K
Automatic Separation and Collection of Cancer-Related Substances from Clinical Samples
08:49

Automatic Separation and Collection of Cancer-Related Substances from Clinical Samples

Published on: January 13, 2023

2.0K

Area of Science:

  • Biomedical Engineering
  • Molecular Diagnostics
  • Cancer Research

Background:

  • Liquid biopsy enables noninvasive molecular profiling for precise patient diagnosis.
  • Extracellular vesicles (EVs) and circulating tumor cells (CTCs) contain vital disease information.
  • Efficient isolation of EVs and CTCs requires high-performance recognition ligands.

Purpose of the Study:

  • To review advanced strategies for evolving high-performance aptamers.
  • To discuss aptamer-based biomaterials and biointerfaces for EV and CTC isolation/analysis.
  • To explore the clinical utility and future directions of aptamer-based liquid biopsy.

Main Methods:

  • Summarizing recent aptamer evolution strategies.
  • Reviewing aptamer-based recognition element construction.
  • Discussing aptamer-functionalized biomaterials for EV/CTC isolation and analysis.

Main Results:

  • Aptamers demonstrate high specificity and affinity, making them superior ligands for liquid biopsy.
  • Aptamer-based approaches facilitate efficient isolation and analysis of EVs and CTCs.
  • The review consolidates current advancements in aptamer-driven liquid biopsy.

Conclusions:

  • Aptamers are crucial for developing advanced liquid biopsy techniques.
  • Aptamer-based methods show significant potential for precise cancer diagnosis and monitoring.
  • Addressing challenges is key to realizing the full clinical utility of aptamer-based liquid biopsy.