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Updated: Oct 7, 2025
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A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy
Published on: February 21, 2025
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Employing Synthetic T-cell Biology to Target AML without On-Target/Off-Cancer Toxicity
M Paulina Velasquez1, Stephen Gottschalk2
1Department of Bone Marrow Transplant and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, Tennessee.
Blood Cancer Discovery
|January 11, 2022
Abstract:
Ideal targets for chimeric antigen receptor T-cell therapy for acute myeloid leukemia (AML) remain elusive. In this issue of Blood Cancer Discovery, Richards and colleagues explore CD93 as a potential AML target antigen, and devise an approach to mitigate "on-target/off-cancer toxicity."See related article by Richards et al., p. 648.
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