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L-5-hydroxytryptophan attenuates positive psychotic symptoms induced by D-amphetamine
M R Irwin1, S R Marder, F Fuentenebro
1Veterans Administration Medical Center, Clinical Research Center on Alcoholism, San Diego, CA 92161.
Psychiatry Research
|December 1, 1987
Abstract:
Brain serotonin has been hypothesized to be involved in the modulation of psychotic symptoms in at least some forms of schizophrenia. We examined the effects of the serotonin precursor L-5-hydroxytryptophan (5HTP) on D-amphetamine induction of acute psychotic symptoms in schizophrenic patients. Preadministration with 5HTP significantly antagonized amphetamine-elicited elevations in thought disturbance, activation, and hallucinations.