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Spider-Inspired Multicomponent 3D Printing Technique for Next-Generation Complex Biofabrication.

You Zhou1, Shenglong Liao1, Xinglei Tao1

  • 1Department of Chemistry, Renmin University of China, Beijing 100872, China.

ACS Applied Bio Materials
|January 12, 2022
PubMed
Summary

A novel spider-inspired 3D printing (SI-3DP) technique enables continuous, multicomponent biofabrication. This 3D printing method shows promise for creating complex artificial tissues and organs for regenerative medicine.

Keywords:
3D printinghydrogelin situ gelationmulticomponentspider-inspired

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Tissue shortages pose significant challenges for clinical therapies treating tissue loss and organ failure.
  • 3D printing offers potential for tissue engineering by constructing 3D tissue-mimicking objects from cells and biomaterials.
  • Fabricating complex artificial living tissues and organs remains challenging due to biological complexity.

Purpose of the Study:

  • To introduce a novel spider-inspired 3D printing (SI-3DP) technique for continuous multicomponent biofabrication.
  • To demonstrate the capability of SI-3DP in rapidly constructing 3D architectures with precise control over component placement.
  • To evaluate the potential of SI-3DP for biomedical applications, including the fabrication of vascularized structures.

Main Methods:

  • Development of a spider-inspired 3D printing (SI-3DP) technique utilizing in situ gelation at a multibarrel printing nozzle.
  • Continuous printing of multiple bio-inks to create complex 3D architectures.
  • Fabrication of vessel-like hollow hydrogel microfibers and cell-laden hollow fibers to assess biocompatibility and application potential.

Main Results:

  • The SI-3DP technique enables rapid, continuous, and precise construction of 3D architectures using multiple components.
  • Successful printing of vessel-like hollow hydrogel microfibers and cell-laden hollow fibers was achieved.
  • The technique demonstrated good biocompatibility, suggesting suitability for biomedical applications.

Conclusions:

  • The developed SI-3DP technique offers a promising approach for advanced biofabrication.
  • This innovative 3D printing method has the potential to overcome limitations in creating complex biological structures.
  • SI-3DP is envisioned to advance the development of next-generation artificial tissues and organs for clinical use.