Multicomponent Reactions-Based Modified/Functionalized Materials in the Biomedical Platforms

In various physiological and biological functions, bioactive materials as a key technique or procedure hold promise for the achievement of therapeutic effects in animals or humans. Interesting merit in the biomedical field is the emergence of a neoteric strategy for functionalization of materials. Expressly, the combination of multicomponent reactions (MCRs) with materials chemistry is the modernizaation of functionalized architectures with flexible features and opens an interesting avenue for biologically relevant scaffold structures. MCRs have attracted great attention from the community of medicinal chemistry owing to their intrinsic molecular diversity, great efficiency, and pot and atom economy with simple operation. Besides, as the main green chemistry metrics, MCRs can improve the mass intensity and E-factor. In this review, an overview of recent works is presented regarding this unprecedented subject to inspire vision for applications of MCRs in the materials biomedical platform.