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Updated: Oct 7, 2025
IridiumIII Luminescent Probe for Detection of the Malarial Protein Biomarker Histidine Rich Protein-II
Published on: July 7, 2015
Multiphoton Absorption Iridium(III)-Organotin(IV) Dimetal Complex with AIE Behavior for Both Sensitive Detection of
Qiong Zhang1, Xin Lu1, Hongzhi Cao2
1College of Chemistry and Chemical Engineering, Institutes of Physics Science and Information Technology, Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials, Anhui University, Hefei 230601, P.R. China.
Abstract:
Multiphoton absorption chromophores have emerged as an attractive class of fluorescent agents for bioimaging in recent years. Here, we first report a cyclometalated Iridium(III)-organotin(IV) dimetal complex, which exhibits efficient multiphoton (from two- to three-photon) fluorescence. The three-photon absorption of IrSn1 is located in the NIR-II (second near-infrared window (900-1700 nm)) region. IrSn1 obtained aggregation-induced emission (AIE), emitting bright orange fluorescence (595 nm). IrSn1 can specifically target tyrosine, which shows an obvious multiphoton fluorescence enhancement under NIR-II region. Importantly, IrSn1 is alsoprovided a visible antibacterial activity toward Staphylococcus aureus in vitro and in vivo. Two-photon fluorescence bioimages and stimulated emission depletion (STED) microscopy indicated that IrSn1 could specifically recognize the nuclear thus leading DNA breaking in Staphylococcus aureus and cancer cells.
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