3D Biofabrication Using Living Cells for Applications in Biohybrid Sensors and Actuators

In this paper, we highlight the concept of biohybrid sensors and actuators built by incorporating living cells into artificial systems. Instead of using the materials extracted from cells, these approaches utilize cells to dynamically generate functional materials and to provide the native intracellular environment for the proper functioning of the materials. By incorporating the functional cells into artificial devices/chips, the cell-based biohybrid approaches can be applied to create portable odorant sensors with high sensitivity and to create biohybrid muscle actuators for applications in both drug screening and soft robotics.