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Trimethoprim associated aseptic meningitis.

J Carlson¹, B E Wiholm

¹Department of Drugs, University Hospital, Uppsala, Sweden.

Scandinavian Journal of Infectious Diseases

|January 1, 1987

Summary

Trimethoprim-containing medications can cause recurrent aseptic meningitis, a likely adverse drug reaction. Symptoms appear rapidly after intake, and the condition

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Area of Science:

Pharmacology
Neurology
Immunology

Background:

Trimethoprim is an antibiotic commonly used to treat bacterial infections.
Recurrent meningitis is a serious condition requiring prompt diagnosis and management.

Observation:

Five patients experienced recurrent meningitis episodes temporally linked to trimethoprim intake.
Some patients received pure trimethoprim before the reaction.
Three patients had established autoimmune diseases.

Findings:

A close temporal relationship was observed, with symptoms appearing within minutes of drug intake.
No infectious agents were identified, indicating aseptic meningitis.
Lumbar punctures normalized after recovery in observed patients.

Implications:

Aseptic meningitis is a probable adverse drug reaction associated with trimethoprim.
The incidence of this reaction may be underestimated in clinical practice.
Clinicians should consider trimethoprim as a potential cause of recurrent aseptic meningitis.

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