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Updated: Oct 7, 2025

A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound
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18F-PSMA-11 PET/MRI in Prostate Adenocarcinoma With Mucinous Features

Qian Zhao1, Bo Yang2, Aisheng Dong3

  • 1From the Department of Nuclear Medicine, General Hospital of Ningxia Medical University, Yinchuan, Ningxia.

Clinical Nuclear Medicine
|January 12, 2022
PubMed

Insights

Primary mucinous prostate adenocarcinoma is rare. Findings suggest prostate-specific membrane antigen (PSMA) PET/MRI can help detect this uncommon variant, aiding diagnosis.

Area of Science:

  • Oncology
  • Radiology
  • Nuclear Medicine

Background:

  • Primary mucinous adenocarcinoma is a rare variant of prostate cancer.
  • Accurate detection and characterization of rare prostate cancer subtypes are crucial for effective management.

Observation:

  • This study details the magnetic resonance imaging (MRI) and 18F-PSMA-11 positron emission tomography/MRI (PET/MRI) findings in a patient with prostate adenocarcinoma exhibiting mucinous features.
  • The tumor demonstrated characteristic inhomogeneous hyperintensity on T2-weighted MRI sequences, attributed to high extracellular mucin content.
  • Inhomogeneous uptake of 18F-PSMA-11 was observed, with a maximum standardized uptake value (SUVmax) of 12.5.

Findings:

  • The observed MRI characteristics correlate with the presence of mucin.
  • PSMA PET/MRI revealed specific uptake patterns in the mucinous prostate tumor.
  • The SUVmax of 12.5 indicates a certain level of PSMA expression in this tumor variant.

Implications:

  • PSMA PET/MRI may serve as a valuable imaging modality for identifying and characterizing primary mucinous prostate adenocarcinoma.
  • This imaging approach could improve the diagnostic accuracy for this uncommon prostate cancer subtype.
  • Further research into PSMA PET/MRI in mucinous prostate adenocarcinoma could refine diagnostic criteria and treatment strategies.

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