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Updated: Oct 7, 2025
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Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots
Published on: August 16, 2020
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Infiltration of subcutaneous adipose layer into the dermal layer with aging
Tomonobu Ezure1, Satoshi Amano1, Kyoichi Matsuzaki2
1MIRAI Technology Institute, Shiseido Co., Ltd., Yokohama-shi, Japan.
Summary
As skin ages, subcutaneous fat infiltrates the dermal layer, causing structural changes. Advanced 3D analysis technology reveals these age-dependent alterations in skin
Area of Science:
- Dermatology
- Biomedical Engineering
- Aging Research
Background:
- Dermal elasticity decreases with age, contributing to wrinkles and ulcers.
- The exact mechanisms are unclear due to the complexity of dermal structure.
- Understanding age-related skin changes is crucial for developing effective treatments.
Purpose of the Study:
- To investigate age-dependent changes in the three-dimensional (3D) dermal structure.
- To utilize advanced 3D analysis technology for detailed skin structure examination.
Main Methods:
- X-ray micro computed tomography (micro CT) was used to observe sun-protected human skin.
- Skin layers (epidermis, dermis, subcutaneous adipose tissue) were identified and digitally reconstructed in 3D.
- Statistical analysis compared structural changes between young and aged skin samples.
Main Results:
- Aged skin showed significant infiltration of subcutaneous fat into the dermal layer.
- Ectopic fat deposits, initially appearing isolated, were confirmed to be connected to the subcutaneous adipose layer.
- 3D reconstruction clearly visualized the increased severity of fat infiltration in aged skin.
Conclusions:
- Subcutaneous fat infiltration into the dermis is a key age-dependent change in skin structure.
- 3D analysis technology provides valuable insights into complex internal skin structures and aging processes.
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