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Updated: Aug 7, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
The role of autoantigen in autoimmunity
Abstract:
Autoimmunity in disease is driven by autoantigen. Cell surface molecules may stimulate autoreactive T-helpers if class II MHC is expressed; special factors may predispose to the ease of class II induction. Soluble autoantigens may be focused by primed B cells and processed for presentation to T cells. Autoantigenicity may be influenced by metabolic events: (a) Poorly iodinated thyroglobulin does not induce thyroiditis, and (b) IgG in rheumatoid arthritis has galactose deficient Fc oligosaccharides. Glycosylation defects may prove to have wide implications.
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