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A systematic review on papers that study on Single Nucleotide Polymorphism that affects coronavirus 2019 severity
Siyeon Suh1,2, Sol Lee1, Ho Gym1
1BASGENBIO Inc. LTD, Seoul, South Korea.
BMC Infectious Diseases
|January 13, 2022
Summary
This study identifies key genes like ACE2, TMPRSS2, and IFITM3 associated with SARS-CoV-2 infection and severity. Specific single nucleotide polymorphisms (SNPs) linked to these genes may influence infection risk and disease outcomes.
Area of Science:
- Genetics
- Infectious Diseases
- Global Health
Background:
- Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causes COVID-19, a significant global health threat.
- Understanding genetic factors influencing SARS-CoV-2 infection and disease severity is crucial for public health strategies.
- Genetic similarities among infected individuals may reveal patterns of transmission and disease progression.
Purpose of the Study:
- To review and analyze existing literature on Single Nucleotide Polymorphisms (SNPs) associated with SARS-CoV-2 infection and severity.
- To identify frequently reported genes and specific SNPs linked to COVID-19 outcomes.
Main Methods:
- A systematic literature search was conducted on PubMed for studies on SNPs and SARS-CoV-2.
- Included were human clinical studies with statistical relevance to virus infection.
- Quality assessment was performed using the Newcastle Ottawa Scale.
Main Results:
- 21 studies involving 63,496 cases were included.
- ACE2, TMPRSS2, and IFITM3 were the most frequently implicated genes in SARS-CoV-2 infection.
- Specific SNPs (rs12252-C, rs143936283, rs2285666, rs41303171, rs35803318) were mentioned in multiple studies.
Conclusions:
- ACE2, TMPRSS2, and IFITM3 are major genes influencing SARS-CoV-2 infection.
- Identified SNPs are linked to these key genes and may affect infection susceptibility and severity.
- Further research is needed due to the limited historical data on COVID-19.
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