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A Description of COVID-19-Directed Therapy in Children Admitted to US Intensive Care Units 2020

Jennifer E Schuster1, Natasha B Halasa2, Mari Nakamura3,4

  • 1Division of Pediatric Infectious Diseases, Department of Pediatrics, Children's Mercy Kansas City, Kansas City, Missouri, USA.

Journal of the Pediatric Infectious Diseases Society
|January 13, 2022
PubMed

Insights

More than half of critically ill children with COVID-19 received directed therapies, including steroids and remdesivir. This study highlights treatment patterns in pediatric intensive care units during the pandemic.

Area of Science:

  • Pediatric critical care medicine
  • Infectious diseases
  • Pharmacology

Background:

  • Limited data exists on the use of COVID-19 treatments in critically ill children.
  • Understanding treatment patterns is crucial for managing severe pediatric COVID-19 cases.

Purpose of the Study:

  • To describe the characteristics of critically ill children who received COVID-19-directed therapies.
  • To identify the specific therapies administered to these children.
  • To analyze trends in therapy use over time.

Main Methods:

  • Retrospective analysis of 424 children (<18 years) in intensive care or step-down units across 48 US pediatric hospitals.
  • Comparison of demographics, clinical data, and outcomes between children who received and did not receive COVID-19-directed therapies.
  • Evaluation of temporal trends in the administration of specific therapies.

Main Results:

  • 55% (235/424) of children received COVID-19-directed therapies.
  • Children receiving therapies were older, more likely to have underlying conditions, and required more respiratory support.
  • Systemic steroids (73%) and remdesivir (64%) were the most common therapies, with remdesivir use increasing significantly over the study period.

Conclusions:

  • Over half of critically ill children with COVID-19 received directed therapies, despite a lack of pediatric-specific evidence.
  • Treatment patterns included significant use of systemic steroids and remdesivir.
  • Further research is needed to optimize COVID-19 treatment strategies for pediatric populations.
Abstract

Keywords:
COVID-19intensive care unitpediatricremdesivirtreatment

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