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Deubiquitinase JOSD2 stabilizes YAP/TAZ to promote cholangiocarcinoma progression

Meijia Qian1, Fangjie Yan2, Weihua Wang1

  • 1Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.

Acta Pharmaceutica Sinica. B
|January 13, 2022
PubMed

Keywords:
CCA, cholangiocarcinomaCholangiocarcinomaDAB, 3,3-diaminobenzidine tetrahydrochloride chromogenDUB, deubiquitinaseDeubiquitinaseFGFR, fibroblast growth factor receptorFOLFOX, folinic acid, 5-FU and oxaliplatinIDH1/2, isocitrate dehydrogenase 1/2IHC, immunohistochemistryIP, immunoprecipitationJOSD2KRAS, kirsten rat sarcoma 2 viral oncogene homologLATS1/2, large tumor suppressor kinase 1/2MST1/2, mammalian Ste20-like kinases 1/2OTUB2, otubain-2PBS, phosphate-buffered salinePDC, patient derived cellPDX, patient-derived xenograftRTV, relative tumor volumeSRB, sulforhodamine BTAZ, transcriptional co-activator with PDZ-binding motifTCGA, The Cancer Genome AtlasUSP9X/10/47, ubiquitin-specific peptidase 9X/10/47YAP, Yes-associated proteinYAP/TAZYOD1, ubiquitin thioesterase OTU1rhJOSD2, recombinant human JOSD2shRNA, specific hairpin RNA

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