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Induction and Analysis of Epithelial to Mesenchymal Transition
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Epithelial-mesenchymal transition process during embryo implantation
Farnaz Oghbaei1, Reza Zarezadeh2, Davoud Jafari-Gharabaghlou2
1Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran.
Cell and Tissue Research
|January 13, 2022
Summary
Improper epithelial-mesenchymal transition (EMT) in embryo and uterine cells can lead to implantation failure. This review summarizes key factors regulating EMT during this critical reproductive process.
Area of Science:
- Reproductive biology
- Cellular biology
- Developmental biology
Background:
- Embryo implantation requires epithelial-mesenchymal transition (EMT) in both embryonic and endometrial cells.
- Dysregulation of EMT is a potential cause of implantation failure.
- While EMT in cancer is well-studied, its role in implantation is less understood.
Purpose of the Study:
- To comprehensively review factors regulating EMT during embryo implantation.
- To highlight the importance of tightly regulated EMT for successful reproduction.
Main Methods:
- Literature review of studies on EMT during embryo implantation.
- Analysis of regulatory factors including hormones, growth factors, transcription factors, microRNAs, aquaporins, and ion channels.
- Examination of signaling pathways affecting epithelial and mesenchymal markers.
Main Results:
- EMT is crucial for conceptus-endometrium interaction.
- Numerous factors influence EMT, impacting cellular markers and cytoskeleton.
- Specific regulatory mechanisms in implantation-related EMT require further elucidation.
Conclusions:
- EMT is a critical, multifactorial process in embryo implantation.
- Understanding EMT regulation is key to addressing implantation failure.
- Further research is needed to fully elucidate EMT mechanisms in reproductive contexts.
Keywords:
AquaporinsEmbryo implantationEndometriumGrowth factorsMicroRNAsSteroidsTranscription factorsTrophoblastMore Related Videos
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