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Nanozyme-Triggered DNA Release from Alginate Films.

Daniel Massana Roquero1, Paolo Bollella1, Artem Melman1

  • 1Department of Chemistry and Biomolecular Science, Clarkson University, 8 Clarkson Avenue, Potsdam, New York 13699, United States.

ACS Applied Bio Materials
|January 13, 2022
PubMed
Summary
This summary is machine-generated.

This study developed a novel alginate hydrogel system for controlled DNA release. Gold nanoparticles act as nanozymes, using a glucose signal to trigger DNA release via hydrogen peroxide production and hydrogel degradation.

Keywords:
DNAalginate hydrogelbiomolecular signalcontrolled releasenanozyme

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Area of Science:

  • Biomaterials Engineering
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Alginate hydrogels are widely used for biomolecule encapsulation.
  • Uncontrolled leakage of biomolecules from alginate hydrogels remains a challenge.
  • Nanozymes offer catalytic functions for controlled release applications.

Purpose of the Study:

  • To develop a signal-triggered system for controlled DNA release from alginate hydrogels.
  • To utilize gold nanoparticles (Au NPs) as nanozymes to initiate hydrogel degradation.
  • To investigate the mechanism of glucose-responsive DNA release.

Main Methods:

  • Electrochemical production of alginate hydrogel thin films.
  • Incorporation of gold nanoparticles (Au NPs) as nanozymes.
  • Utilizing glucose oxidase-mimicking activity of Au NPs to produce H2O2.
  • Fenton-type reaction with Fe3+ to generate free radicals for hydrogel degradation.
  • Monitoring DNA release triggered by glucose signal.

Main Results:

  • Au NPs catalyzed glucose oxidation, producing H2O2.
  • H2O2 initiated a Fenton-type reaction, degrading the alginate matrix.
  • Degradation of the hydrogel led to the release of entrapped DNA molecules.
  • Demonstrated signal-triggered DNA release in various system configurations.
  • Successfully addressed uncontrolled DNA leakage issues.

Conclusions:

  • Developed a glucose-responsive alginate hydrogel system for controlled DNA release.
  • Nanozyme-mediated hydrogel degradation provides a mechanism for triggered biomolecule release.
  • This approach enhances the functionality of nanozymes in smart biomaterial systems.