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Reconfigurable Surface with Photodefinable Physicochemical Properties for User-Designable Cell Scaffolds.

Wei Hou1,2, Yuli Wang3,4, Yifeng Bian3,4

  • 1School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China.

ACS Applied Bio Materials
|January 13, 2022
PubMed
Summary

Researchers developed a novel reconfigurable surface with adjustable topography and chemical properties using light. This smart surface allows on-demand control over its features, enabling user-designed cell scaffolds for precise control of cell behavior.

Keywords:
cell scaffolddisulfideorgan-on-a-chipphotochemistryreconfigurable surface

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Area of Science:

  • Materials Science
  • Surface Chemistry
  • Biotechnology

Background:

  • Static or switchable surfaces limit applications in areas like functional interfaces and cell scaffolds.
  • Developing on-demand regulated surfaces is crucial for creating advanced smart materials.
  • Existing methods often result in surfaces with fixed or binary properties.

Purpose of the Study:

  • To present a reconfigurable surface with adjustable topography and chemical functionality.
  • To utilize the photodynamic properties of disulfide bonds for light-induced surface modification.
  • To demonstrate the creation of user-designable cell scaffolds with controlled bioactivity.

Main Methods:

  • Fabrication of structured surfaces using disulfide-cross-linked polymer networks from disulfide-containing methacrylate monomers.
  • On-demand regulation of surface topography using 254 nm UV light.
  • On-demand regulation of surface chemical functionality using 365 nm UV light.

Main Results:

  • Demonstrated light-induced, on-demand adjustment of both surface topography and chemical functionality.
  • Showcased the ability to define physicochemical properties of the surface using specific UV wavelengths.
  • Successfully generated user-designable cell scaffolds from a single original surface.

Conclusions:

  • The developed photodynamic disulfide-based surface offers unprecedented control over surface properties.
  • This technology enables the creation of smart surfaces with tunable topography and chemistry for diverse applications.
  • The user-designable cell scaffolds allow precise control over cell behaviors by defining localized bioactivity.