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Updated: Oct 13, 2026

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
Published on: February 19, 2016
Acetal-Functionalized Pillar[5]arene: A pH-Responsive and Versatile Nanomaterial for the Delivery of Chemotherapeutic
Shang Lan1, Yamin Liu1, Kejia Shi1
1Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China.
Abstract:
Acetal-functionalized pillar[5]arene (Ac-PA[5]) was prepared as a pH-responsive biomaterial. This biomaterial could be fabricated into nanoparticles with a narrow size distribution by an emulsion protocol. PA[5]-based nanoparticles were used to deliver anti-tumor drugs (paclitaxel and doxorubicin) in vitro. PA[5]-based nanoparticles were discovered to be a versatile drug delivery system (DDS) to incorporate a fluorescent dye (fluorescein) or a targeting group (folic acid) via host-guest interactions. The resulting DDS could be used for the purpose of bioimaging or targeted delivery. Acetal-functionalization renders the system acid-labile to release encapsulated cargo during cell internalization, which is confirmed by confocal laser scanning microscopy (CLSM). A folic-acid-modified DDS shows a 5.1-fold enhancement in bioactivity in vitro due to the targeting effect. This DDS is a platform to conveniently integrate multiple functions.
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