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Related Experiment Video

Updated: Oct 6, 2025

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Chemically Modified Aptamers in Biological Analysis.

Ruichen Shen1, Jie Tan1, Quan Yuan1,2

  • 1Institute of Chemical Biology and Nanomedicine (ICBN), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.

ACS Applied Bio Materials
|January 13, 2022
PubMed
Summary
This summary is machine-generated.

Chemically modified nucleic acid aptamers offer enhanced functions for biological analysis. This review highlights their synthesis, screening, and applications, paving the way for versatile aptamer-based platforms.

Keywords:
aptamerbiomarker detectionmodified nucleotidesprotein activity regulationsequence analysistumor treatment

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Analytical Chemistry

Background:

  • Nucleic acid aptamers are increasingly utilized in biological analysis due to their high affinity, selectivity, and programmability.
  • Chemical modifications can impart novel spatial conformations and functionalities to aptamers, expanding their bioanalytical applications.
  • Existing reviews predominantly focus on aptamer-functional material complexes, with limited attention to chemically modified aptamers themselves.

Purpose of the Study:

  • To introduce the synthesis and screening methodologies for chemically modified nucleic acids.
  • To summarize recent advancements in the bioanalytical applications of chemically modified aptamers.
  • To underscore the potential of chemically modified aptamers as a versatile platform for biological analysis.

Main Methods:

  • Review of literature on synthesis and screening of chemically modified nucleic acids.
  • Compilation and analysis of recent studies employing chemically modified aptamers in bioanalysis.
  • Focus on aptamer modifications that enhance spatial conformations and functions.

Main Results:

  • Chemically modified aptamers demonstrate diverse spatial conformations and enhanced functionalities.
  • These modifications expand the scope of aptamer applications in various bioanalytical techniques.
  • The review consolidates knowledge on chemically modified aptamers, distinct from aptamer-material complexes.

Conclusions:

  • Chemically modified aptamers represent a significant advancement in aptamer technology for bioanalysis.
  • Further research into synthesis and screening will unlock new applications.
  • These modified aptamers offer a promising foundation for developing versatile, high-performance bioanalytical platforms.