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Rare Case of Small Cell Metastatic Prostatic Adenocarcinoma, Properly Staged by 68Ga-PSMA PET/CT Scan
Zahra Bakhshi Golestani1, Salman Soltani2, Mahmoud Reza Kalantari3
1From the Nuclear Medicine Research Center.
Clinical Nuclear Medicine
|January 13, 2022
Summary
This case study highlights a rare aggressive prostate cancer, small cell carcinoma (SCC). Gallium-68 PSMA PET/CT imaging revealed unexpected uptake in this aggressive prostate SCC, aiding in staging.
Area of Science:
- Urology
- Oncology
- Nuclear Medicine
Background:
- Small cell carcinoma (SCC) of the prostate is an exceptionally rare and aggressive neuroendocrine malignancy.
- Prostate SCC diagnosis is typically confirmed via biopsy, with staging crucial for treatment planning.
Observation:
- A 60-year-old male patient presented with biopsy-proven prostatic SCC (Gleason score 5+5).
- The patient underwent Gallium-68 PSMA PET/CT for staging purposes.
Findings:
- The 68Ga-PSMA PET/CT scan demonstrated significant PSMA uptake in the prostate bed.
- Multiple enlarged pelvic lymph nodes also exhibited PSMA uptake, indicating metastatic disease.
Implications:
- This case suggests that 68Ga-PSMA PET/CT may be a valuable imaging tool for staging de novo prostate SCC.
- Further research is warranted to understand the prevalence and significance of PSMA uptake in prostate SCC.
- This imaging approach could potentially improve the management of patients with this rare and aggressive cancer.
