Immunogenicity of Nickel-Further Explored

Recent reports of the relationship between nickel, allergy and autoimmunity have been described. However, there remains a lack of information on the concordance between nickel sensitization and potency. Of note, an article by Drenovska et al. recommended a call for increased epidemiologic studies to define the prevalence of autoimmune syndromes induced by adjuvants such as nickel-containing metal implants. Accumulating reports of dermatologic manifestations following medical device implantation highlights the need for consideration regarding the potential sequelae following metal implantation. Considering the medical and the functional necessity of certain device materials, the authors agree calling for further epidemiological studies are needed to prevent metal-related autoimmunity, and additionally discover novel testing strategies.