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Effect of cimetidine and pyrilamine on histamine-induced ocular surface hyperemia
D F Woodward1, L Johnson, C Spada
1Discovery Research, Allergan Eye and Skin Care Group, Irvine, California.
Journal of Ocular Pharmacology
|January 1, 1986
Abstract:
Histamine-induced ocular surface redness was virtually abolished by a combination of cimetidine (H2-receptor antagonist) and pyrilamine (H1-receptor antagonist), whereas either antagonist administered alone produced no significant reduction. It appears that combined H1- and H2-antagonist therapy is required for effective blockade of ocular responses to histamine that involve both receptor subtypes.