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Updated: Oct 6, 2025

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
Published on: February 19, 2021
Calibrationless multi-slice Cartesian MRI via orthogonally alternating phase encoding direction and joint low-rank
Yujiao Zhao1,2, Zheyuan Yi1,2,3, Yilong Liu1,2
1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
This study introduces a new multi-slice MRI method using alternating phase encoding directions for faster, clearer images. It significantly reduces artifacts, improving magnetic resonance imaging quality without calibration.
Area of Science:
- Medical Imaging
- Magnetic Resonance Imaging (MRI)
- Image Reconstruction
Background:
- Accelerated MRI acquisition is crucial for reducing scan times.
- Current multi-slice MRI methods face challenges with aliasing artifacts and reconstruction quality.
- Calibrationless reconstruction methods are desirable for practical MRI applications.
Purpose of the Study:
- To develop and evaluate a novel multi-slice MRI acquisition and reconstruction strategy for accelerated 2D Cartesian imaging.
- To improve image quality and reduce aliasing artifacts in accelerated multi-slice MRI.
- To enable calibrationless parallel imaging for multiple 2D slices.
Main Methods:
- Acquisition of multi-slice, multi-channel MRI data with orthogonally alternating phase encoding (PE) directions between adjacent slices.
- Application of random or uniform PE undersampling.
- Joint reconstruction using a low-rank multi-slice Hankel tensor completion (MS-HTC) approach.
- Evaluation using human brain MR data.
Main Results:
- The proposed method effectively suppressed aliasing artifacts at high acceleration factors.
- It outperformed existing MS-HTC approaches with consistent PE directions.
- Robust performance was observed with both uniform and random undersampling, without requiring central k-space lines.
- Improved image reconstruction quality was achieved.
Conclusions:
- The novel strategy leverages coil sensitivities and inter-slice image similarities for enhanced reconstruction.
- Orthogonally alternating PE directions significantly aid the low-rank completion process and improve image quality.
- This method is applicable to various undersampling schemes and facilitates practical, calibrationless Cartesian parallel imaging for multi-slice MRI.
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