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The interplay between sleep and gut microbiota.

Mengqi Han¹, Shiying Yuan¹, Jiancheng Zhang¹

¹Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Brain Research Bulletin

|January 15, 2022

Summary

This summary is machine-generated.

The gut microbiota (GM) influences sleep quality, and disrupted sleep affects GM composition. Understanding the brain-gut-microbiota axis (BGMA) reveals therapeutic targets for sleep improvement.

Keywords:

Brain-gut-microbiota axis Circadian misalignment Gut microbiota Insomnia Obstructive sleep apnea Sleep Sleep deprivation Sleep fragmentation

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Area of Science:

Microbiology
Neuroscience
Physiology

Background:

Sleep is vital for physiological functions.
The gut microbiota (GM) impacts metabolic, immunological, and neurobehavioral functions.
The brain-gut axis facilitates bidirectional communication between the brain and gut.

Purpose of the Study:

To explore the intricate relationship between sleep and the gut microbiota.
To elucidate the mechanisms underlying the brain-gut-microbiota axis (BGMA) in sleep regulation.
To identify potential therapeutic microbiota manipulations for enhancing sleep quality.

Main Methods:

Literature review of existing research on sleep and gut microbiota.
Analysis of studies investigating the brain-gut-microbiota axis (BGMA).
Examination of factors influencing the BGMA, including immune, neural, and metabolic pathways.

Main Results:

The gut microbiota is essential for maintaining normal sleep physiology.
Abnormal sleep patterns can alter GM composition, diversity, and function via the BGMA.
Immune system, vagus nerve, neuroendocrine system, and bacterial metabolites are key players in the BGMA.

Conclusions:

The gut microbiota plays a significant role in sleep regulation.
Therapeutic interventions targeting the GM show promise for improving sleep quality.
Further research into the BGMA is crucial for developing novel sleep therapies.