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Hyperpolypharmacy and Frailty in Kidney Transplant Recipients
Akihiro Kosoku1, Tomoaki Iwai1, Kazuya Kabei2
1Department of Urology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Hyperpolypharmacy, defined as taking 10 or more medications daily, is common in kidney transplant recipients (KTRs). This study found a significant association between hyperpolypharmacy and increased frailty in KTRs.
Area of Science:
- Nephrology
- Gerontology
- Clinical Pharmacy
Background:
- Kidney transplant recipients (KTRs) commonly use multiple daily medications, including immunosuppressants.
- The relationship between polypharmacy and frailty is established but not well-defined in KTRs.
Purpose of the Study:
- To investigate the association between hyperpolypharmacy and frailty in kidney transplant recipients.
Main Methods:
- A cross-sectional study involving 211 KTRs at Osaka City University Hospital.
- Frailty assessed using the Kihon Checklist (KCL); hyperpolypharmacy defined as ≥10 daily oral medications.
- Statistical analyses included multivariable logistic and linear regression.
Main Results:
- 41% of KTRs exhibited hyperpolypharmacy (mean 9.4 medications).
- Hyperpolypharmacy significantly correlated with higher KCL scores and increased odds of frailty (OR 5.70).
- An optimal cutoff of 12 medications predicted frailty with an AUC of 0.81.
Conclusions:
- Hyperpolypharmacy is prevalent among kidney transplant recipients.
- A strong association exists between hyperpolypharmacy and frailty in this population.
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