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Recent advances in induced proximity modalities.

Christine S C Ng1, Steven M Banik2

  • 1Department of Chemistry, Stanford University, Stanford, CA, USA.

Current Opinion in Chemical Biology
|January 16, 2022
PubMed
Summary
This summary is machine-generated.

New therapeutic strategies rewire protein interactions using proximity-inducing agents. These agents offer novel ways to target diseases by enabling protein degradation, cleavage, and editing beyond traditional methods.

Keywords:
BiologicsCRISPRLYTACMolecular gluePROTACProteomicsProximityRIPR

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Area of Science:

  • Biochemistry and Molecular Biology
  • Drug Discovery and Development
  • Chemical Biology

Background:

  • Challenging disease targets require innovative therapeutic interventions beyond conventional agonism or inhibition.
  • Protein-biomolecule interactions can be modulated using proximity-inducing agents, expanding therapeutic avenues.
  • Existing methods for targeting diseases are limited, necessitating novel approaches.

Purpose of the Study:

  • To review recent advancements in induced proximity-driven therapeutic strategies.
  • To highlight key technological breakthroughs enabling new applications of proximity-inducing agents.
  • To explore the diverse mechanisms and target classes amenable to induced proximity approaches.

Main Methods:

  • Literature review of scientific publications from the past two years.
  • Analysis of conceptual and mechanistic developments in induced proximity strategies.
  • Identification of enabling technological advances and their impact.

Main Results:

  • Proximity-inducing agents offer versatile therapeutic modalities including target degradation, cleavage, and post-translational editing.
  • These agents span a wide range of molecular phenotypes and target classes.
  • Recent technological advances have significantly expanded the scope and applicability of induced proximity modalities.

Conclusions:

  • Induced proximity strategies represent a rapidly evolving and promising area for therapeutic intervention.
  • The versatility of proximity-inducing agents allows for targeting previously intractable disease mechanisms.
  • Continued innovation in enabling technologies will further broaden the impact of induced proximity-based therapeutics.