Brain oscillatory dysfunctions in dystonia

Dystonia is a hyperkinetic movement disorder associated with loss of inhibition, abnormal plasticity, dysfunctional sensorimotor integration, and brain oscillatory dysfunctions at cortical and subcortical levels of the central nervous system. Hence, dystonia is considered a network disorder that can, in many cases, be efficiently treated by pallidal deep brain stimulation (DBS). Abnormal oscillatory activity has been identified across the motor circuit of patients with dystonia. Increased low frequency (LF) synchronization in the internal pallidum is the most prominent abnormality. LF oscillations have been associated with the severity of dystonic motor symptoms; they are suppressed by DBS and localized to the clinically most effective stimulation site. Although the origin of these pathologic changes in brain activity needs further clarifications, their characterization will help in adjusting DBS parameters for successful clinical outcome.